Once the domain of bohemian culture, psychedelics are now headed into mainstream medicine. As psychedelic therapy becomes easier to study, mounting evidence is informing new clinical models to treat depression, PTSD, and addiction, smooth the end-of-life passage, and make grief easier to handle. Oregon voters have approved the legalization of psilocybin, a “magic mushroom,” for use under carefully controlled conditions. And at least one company has expanded worker health benefits to cover ketamine, an anesthetic that can produce hallucinations at the right dose, in tandem with counseling. As the use of psychedelics expands, will mental healthcare be transformed?