Many health systems are retooling to provide “patient-centered care,” defined by the Institute of Medicine as a partnership between providers and patients that respects individual preferences, needs, and values. The use of big data to individualize treatment, detect clinical trends, share best practices, and predict the risks of infection and drug side effects is also reshaping patterns of care. And shifting payment strategies inevitably exert an enormous influence on the delivery system. Will a patient-centered, data-centered or payment-centered system ultimately dominate the delivery of health care? Or will it be some combination of them all?