When the University of Texas completes its new medical school campus, it will introduce an entirely different approach to the study of medicine. Self-directed projects, collaborative work spaces, and design thinking will replace memorization and lecture halls, and help to claim a leadership role for academic medicine in addressing the systemic issues that influence health. The University of Utah is also “rethinking everything," working to completely overhaul its curriculum. How is physician education changing to keep the population healthier? How can new strategies for medical training strengthen the evolving health care system?