Conventional wisdom about heart disease was upended twice within a few short months this year. First, the longstanding recommendation urging just about everyone over 50 to take a daily low-dose aspirin to prevent heart attacks was tossed out. Then, we discovered that many people who need to have a heart valve replaced can avoid the rigors of open-heart surgery in favor of a much less invasive technique called transcatheter aortic valve replacement. With the emerging role of artificial intelligence, precision medicine, tissue engineering, and new technologies being implemented in cardiology, it’s hard to keep up. What else is shifting in our approach to preventing heart disease, or treating it when it occurs?