Every day, 91 Americans die following an opioid overdose. The misuse of opioids such as prescription pain relievers, heroin, and fentanyl is a national crisis, with a profound impact on social and economic well-being and on the public health. Although effective treatments for opioid addiction do exist, they are sorely underutilized. Potential therapies to help curtail the epidemic include analgesics with less potential for abuse, alternative approaches to pain relief, more user-friendly formulations of naloxone to counter overdoses, and better remedies for addiction, including new medications and immunotherapies. Can we do better at turning research findings into clinical practice? How do we engage the medical community more fully?