Change, while often incremental, occasionally sweeps in with transformative force. From anesthesia to antibiotics, genomics to artificial intelligence, scientific breakthroughs have already up-ended health and medicine. But innovation keeps accelerating, and countless inventions on the horizon are certain to disrupt how we live, work, and play. Systems and structures are shifting, too, as the organization of medical care takes radically new forms, and public policy alters norms about who gets what, and how it is paid for. Change is a two-way street: as we shatter the frontiers of what is possible, we are being visited by the upheavals of a warming planet, demographic pressures, and growing inequities.